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DHEA mechanism as antidepressant may act via modulation with the GABAARs activity. The GABA ergic system can mediate depression (Lloyd et al., 1989). In depressed patients, cerebral cerebrospinal fluid levels of GABA are lower than in healthy controls (Gerner and Hare, 1981; Gold et alibi, 1980). Furthermore, low GABA content is correlated with depression in post mortem temporal and frontal cortices from patients with Alzheimer’s disease (Garcia Alloza et alibi, 2006). Over these patients, a high density of GABAARs correlates while using the severity of depression. In spite of the increased cortical power of GABA upon antidepressant treatment of healthy individuals (Bhagwagar et aliae, 2004) and electroconvulsive treatment of depressed patients (Sanacora et aliae, 2003), anti depressants that affect GABA haven’t yet been developed 07runescapegolds.com.au. The subunit composition determines the pharmacological properties of GABAAR. Drugs, including neurosteroids, which talk with the receptors, make a difference the subunit mRNA expression (Sun et al, 2004). GABAAR usually contains two two and only a or with all the being rare (Sun et aliae, 2004). GABAARs containing a rather than a tend to be responsive to neurosteroids (Belelli et aliae, 2002), and mice lacking GABAA are less sensitive to neurosteroids (Brown et aliae, 2002;